Personalized medicine modality based on patient-derived xenografts from a malignant transformed GCTB harboring H3F3A G34W mutation
نویسندگان
چکیده
منابع مشابه
H3F3A (Histone 3.3) G34W Immunohistochemistry
Giant cell tumor of bone (GCTB) is a locally aggressive subarticular tumor. Having recently reported that H3.3 G34W mutations are characteristic of this tumor type, we have now investigated the sensitivity and specificity of the anti-histone H3.3 G34W rabbit monoclonal antibody in a wide variety of tumors including histologic mimics of GCTB to assess its value as a diagnostic marker. We also de...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Translation
سال: 2021
ISSN: 2214-031X
DOI: 10.1016/j.jot.2021.04.004